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![]() ![]() With this trial, we will evaluate the safety and efficiency of L-PRF compared to commercially available fibrin sealants. Additionally, a cost-effectiveness analysis is performed. Secondary endpoints are complications such as bleeding or wound infections. The primary endpoint is postoperative CSF leakage within 12 weeks after surgery. Patients are randomized in a 1:1 fashion comparing L-PRF to commercially available fibrin sealants. This trial will include patients undergoing cranial neurosurgery (supratentorial and infratentorial) with intentional opening of the dura. This single-blinded, prospective randomized controlled interventional trial aims to demonstrate the non-inferiority of L-PRF compared to commercially available fibrin sealants for dural closure. This trial aims to investigate autologous leukocyte- and platelet-rich fibrin (L-PRF) as an alternative to commercially available fibrin sealants. Commercially available fibrin sealants are currently considered the gold standard for dural closure, but problems have been reported regarding safety, efficacy, and costs. CSF leakage is a major complication after cranial surgery, thus, adequate dural closure must be performed. |